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HT-1080 cells were transfected with Ex4a(+)WT1 isoform or Mock, and analyzed for apoptosis and mitochondrial damages (Fig 6A). Ex4a(+)WT1 isoform significantly induced apoptosis and mitochondrial membrane possible (MMP) decline in HT-1080 cells. Future, the job on the endogenous Ex4a(+)WT1 isoform in apoptosis was examined. K562 cells were being dealt with with Doxorubicin (Dox) and apoptosis was
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