Ection of effect for the cis-eQTL.Components and Procedures Data productionEthics statement: All mouse function was carried out based on Institutional Animal Care and Use Committee regulations.PLoS Genetics | www.plosgenetics.orgPolygenic cis-Regulatory EvolutionThis method allows us to attain a more correct estimate of local eQTL effect sizes, even in the presence of unlinked trans-eQTLs or corre